B. Douglas Smith, MD Professor of Oncology Division of Hematologic Malignancies Sidney Kimmel Cancer Center at Johns Hopkins Baltimore, MD
AMA PRA Category 1 Credit™ Medium
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Chronic myeloid leukemia (CML) is a myeloproliferative disorder of the bone marrow, accounting for 15% of adult leukemias. Targeted therapy with tyrosine kinase inhibitors (TKIs) has dramatically improved 10-year overall survival for patients with CML from 20% to 80%-90%. To determine the best treatment approach for patients with CML, clinicians must thoroughly understand how to monitor treatment response. The correct interpretation of milestone assessments holds the key to improving physicians’ ability to maintain patients on treatment, to optimize sequencing of treatments if needed, and to improve the quality of patient outcomes.
Presented by the Johns Hopkins University School of Medicine in collaboration with MCM Education.
This educational activity is designed to meet the needs of hematologists and oncologists directly involved in the care of patients with chronic myeloid leukemia. There are no prerequisites.
Upon completion of this educational activity, the participant should be able to:
Create an evidence-based treatment plan for a newly diagnosed CML patient, including a long-term response monitoring program that aligns with current clinical practice guidelines.
Correctly perform and interpret milestone assessments, leading to evidence-based decisions regarding dose escalation, switching to alternative therapies, and toxicity management.
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As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation. The following relationships have been reported for this activity:
B. Douglas Smith, MD, has no conflicts of interest to disclose.
Amir Fathi, MD, has disclosed that he has served as a consultant or advisor for Agios Pharmaceuticals, Ariad Pharmaceuticals, Merck Pharmaceuticals, Seattle Genetics and has received research funding from Exelixis, Seattle Genetics, and Takeda.
Jerald Radich, MD, has disclosed that he has received research funding from Novartis Pharmaceuticals and has served as a consultant or advisor for Novartis, Ariad Pharmaceuticals, and Incyte.
Elias Jabbour, MD, has disclosed that he has received research funding from Pfizer Pharmaceuticals, Ariad Pharmaceuticals, Bristol-Myers Squibb Pharmaceuticals, and Teva Pharmaceuticals.
No other planners have indicated that they have any financial interests or relationships with a commercial entity.
Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution which receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).
Off-Label Product Discussion: No off-label products discussed.
Accreditation Statement:The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation Statement:The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Commercial Support Statements
This activity is supported by an educational grant from Pfizer Inc.
* Estimated time to complete this activity: 30 minutes
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* Take the pre-test
* Review the activity
* Take the post-test and score 75%
* You are allowed a total of 3 attempts
* Complete the evaluation
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credit/participation in this activity
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Reviewed & Approved by:
General Counsel, Johns Hopkins Medicine (4/1/03)
(Updated 4/09 and 3/14)