Discussion Panel Mark A. Socinski, MD (Moderator) Professor of Medicine and Thoracic Surgery University of Pittsburgh School of Medicine Director, Lung Cancer Section Division of Hematology/Oncology UPMC Cancer Centers Co-Director, UPMC Lung Cancer Center of Excellence Co-Director, Lung and Thoracic Malignancies Program Pittsburgh, PA
David Feller-Kopman, MD Director, Bronchoscopy and Interventional Pulmonology Associate Professor of Medicine Johns Hopkins University School of Medicine Baltimore, MD
Ritu Gill, MD Assistant Professor Department of Radiology Harvard Medical School Boston, MA
Lucian Chirieac, MD Associate Professor Department of Pathology Harvard Medical School Boston, MA
CCME Reviewer: Bilal Piperdi, MD Associate Professor of Clinical Medicine Department of Medicine (Oncology) Albert Einstein College of Medicine of Yeshiva University Bronx, NY
AMA PRA Category 1 Credit TM Medium
Non-small cell lung cancer (NSCLC) is the most common lung cancer type, comprising approximately 85% of all lung cancer cases. NSCLC histologies are primarily adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Certain genetic alterations have allowed the further classification of NSCLC into subsets. For example, mutations in the EGFR gene have been identified in nearly 25% of NSCLC cases across the population and ALK rearrangements in nearly 10%. Therapies are now available to target signaling pathways associated with these and other genes. Clinicians who treat NSCLC patients must have a current understanding of the importance of and strategies for obtaining adequate tissue samples for biomarker testing to enable targeted therapy for these patients whenever possible.
This activity is jointly provided by Albert Einstein College of Medicine and Montefiore Medical Center, and MCM Education.
Oncologists, pulmonologists and interventional radiologists (who perform lung biopsies), pathologists, and other oncology clinicians involved in the treatment of patients with NSCLC.
Upon completion of this educational activity, the participant should be able to:
List biomarkers that should be identified in patients with advanced NSCLC based on current guidelines.
Discuss the importance of obtaining adequate tissue samples for treatment decisions in patients with advanced NSCLC.
Explain the challenges that may arise in obtaining an adequate tissue sample and strategies to overcome these challenges.
Describe opportunities for changes in pathology testing processes and procedures to ensure timely and accurate molecular testing for patients with advanced NSCLC.
Describe the safety and efficacy of current targeted treatment strategies for patients with advanced NSCLC.
The “Conflict of Interest Disclosure Policies” of Albert Einstein College of Medicine of Yeshiva University require that faculty participating in any CME activity and anyone in a position to influence content disclose to the audience any relationship(s) with a pharmaceutical or equipment company. Any presenter whose disclosed relationships prove to create a conflict of interest, with regard to their contribution to the activity, will not be permitted to present.
The Albert Einstein College of Medicine of Yeshiva University (Einstein) also require that faculty participating in any CME activity and anyone in a position to influence content disclose to the audience when discussing any unlabeled or investigational use of any commercial product, or device, not yet approved for use in the United States.
Contributors whose COIs are irresolvable are not permitted to participate in Einstein CME activities.
Mark A. Socinski, MD
Grant/Research: Pfizer, Genentech, Eli Lilly, Celgene, Synta, Merrimack
Speakers Bureau: Genentech, Eli Lilly, Celgene
David Feller-Kopman, MD, has no financial conflicts to disclose.
Ritu Gill, MD
Grant/Research: AUR GE
Lucian Chirieac, MD
The staff of CCME of Albert Einstein College of Medicine have no disclosures to report with any commercial interests relative to this CME activity.
Bilal Piperdi, MD, has no financial conflicts to disclose.
Kathleen Hines (MCM Education, Editorial Director) has no financial conflicts to disclose. Credit Statements
ACCME ACCREDITATION STATEMENT: This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through joint sponsorship of Albert Einstein College of Medicine of Yeshiva University, Montefiore Medical Center, and MCM Education. Albert Einstein College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
ACCME CREDIT DESIGNATION STATEMENT: Albert Einstein College of Medicine of Yeshiva University designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit TM. Physicians should claim only the credit commensurate with the extent of their participation in each activity.
Commercial Support Statements
Supported by an independent educational grant from Boehringer Ingelheim.
There are no fees for participating in or receiving credit for this online educational activity.
Participants must view/listen to the activity in its entirety, successfully complete the post-test, and submit an evaluation to receive continuing education credit. Credit will be awarded for a post-test score of 80% or better, and a statement may be printed immediately after passing the post-test online.
Please turn off all pop-up blockers to ensure access to the educational activity.
Click on the "Start program" icon at the bottom of this page. If you are not already registered as a user of this website, this will bring you to the login/registration page where you will be able to register as a new CMEcorner.com member or review your existing registration information. When ready, click on the "Continue to Program" icon at the bottom of the screen. Alternatively, click on "Start as Guest."
The next screen will permit you to check for or download the Flash player required to run this program and to begin the program presentation. The activity will take approximately 60 minutes to complete.
After the activity has finished, click on the "Post-test" button.
Instructions for completing and submitting the post-test and evaluation are provided on the post-test screen.
iPad and iPhone Users
Before Starting Program:
Please be sure to download the Xyvid app. You must launch the program from this application, not from this landing page.
- If you don’t already have it, download the Xyvid app from iTunes: ( http://itunes.apple.com/app/xyvid-pro/id504044816?mt=8)
- If you have the Xyvid app, please check the app store to make sure you have the latest version.
To Start Program:
Please connect via a strong Wi-Fi connection (3G is not recommended).
Be sure to shut off VPN. Go to settings > General > VPN turn off, then Launch the Xyvid app
Once in the Xyvid application, press the continue button (not “view demo”) to enter the iPad Meeting ID: nsclc2013
Ensure that the volume is up on your iPad/iPhone.
- Should you encounter a “frozen” screen, please terminate the Xyvid App. To do this, double click on your home button and hold finger over the Xyvid app until the icons jiggles. Tap the “minus” sign to exit the application – press the home button twice and restart the Xyvid App. Follow instructions above. Certificate Fee
Presented by Albert Einstein College of Medicine & Montefiore Medical Center, Center for Continuing Medical Education, and MCM Education.
The opinions expressed in these educational activities are those of the faculty and do not necessarily reflect the opinions or recommendations of their affiliated institutions, the publisher, Albert Einstein College of Medicine & Montefiore Medical Center, Center for Continuing Medical Education, or Boehringer Ingelheim. Any medications, diagnostic procedures, or treatments discussed by the program presenters should not be used by clinicians or other health care professionals without first evaluating their patients’ conditions, considering possible contraindications or risks, reviewing any applicable manufacturer’s product information, and comparing any therapeutic approach with the recommendations of other authorities.