COURSE DIRECTOR/PRESENTER James O. Armitage, MD Professor of Medicine Joe Shapiro Chair for the Study of Oncology and Clinical Research University of Nebraska College of Medicine Omaha, NE ADDITIONAL CONTENT DEVELOPMENT FACULTY Jeremy Abramson, MD Assistant Professor of Medicine Harvard Medical School Clinical Director, Center for Lymphoma Massachusetts General Hospital Cancer Center Boston, MA
Stephanie A. Gregory, MD, FACP
Professor of Medicine Division of Hematology/Oncology/Cell Therapy Rush University Medical Center Chicago, IL
Steven Horwitz, MD
Associate Professor of Medicine Weill Cornell Medical College New York Presbyterian Hospital New York, NY
Amit K. Verma, MBBS
(CCME Reviewer) Associate Professor of Medicine Albert Einstein College of Medicine Bronx, NY
AMA PRA Category 1 Credit TM Medium
The standards of care in treatment for non-Hodgkin lymphomas (NHL) are evolving as new therapies receive FDA approval and new evidence provides insight into optimal evidence-based approaches. Several key cellular pathways that drive malignant B-cell development have recently been identified and validated, leading to the development of therapies targeting these pathways. Agents targeting the B-cell receptor signaling pathway have been approved for specific types of B-cell NHL, including CLL, FL, and MCL. Ongoing research continues to examine the optimal role of therapies targeting the B-cell receptor pathway. The goal of this CME activity is to increase the ability of hematologists, oncologists, and hematology/oncologists to incorporate B-cell targeted therapies into clinical practice, thus ensuring the best possible outcomes for each patient.
This activity is jointly provided by Albert Einstein College of Medicine and Montefiore Medical Center, and MCM Education.
This educational activity is designed for hematologists, oncologists, pathologists, oncology nurse practitioners, physician assistants, clinical researchers, and others interested in recent advances related to targeted therapies and hematologic malignancies.
Upon completion of this educational activity, the participant should be able to:
Describe the molecular biology of B-cell surface proteins.
Apply the most current evidence for optimal management of the B-cell non-Hodgkin lymphomas.
Apply the most current evidence for optimal management of chronic lymphocytic leukemia.
Describe current evidence for safety and efficacy of emerging and investigational B-cell targeted therapies for B-cell NHL.
The “Conflict of Interest Disclosure Policies” of Albert Einstein College of Medicine require that faculty participating in any CME activity and anyone in a position to influence content disclose to the audience any relationship(s) with a pharmaceutical or equipment company. Any presenter whose disclosed relationships prove to create a conflict of interest, with regard to their contribution to the activity, will not be permitted to present.
The Albert Einstein College of Medicine also require that faculty participating in any CME activity and anyone in a position to influence content disclose to the audience when discussing any unlabeled or investigational use of any commercial product, or device, not yet approved for use in the United States.
Contributors whose COIs are irresolvable are not permitted to participate in Einstein CME activities.
James O. Armitage, MD
Consultant: Celgene, Conatus–IDMC, GlaxoSmithKline–IDMC, Roche, Spectrum, Ziopharm
Board of Directors: Tesaro Bio, Inc.
Jeremy Abramson, MD
Consultant: Gilead, Incyte, Seattle Genetics
Stephanie A. Gregory, MD, FACP
Speakers Bureau: Celgene, Genentech
Fees for Non-CME/CE Services: Pharmacyclics
Steven Horwitz, MD
Consultant: Amgen, Bristol-Myers Squibb, Celgene, Millennium, Seattle Genetics, Spectrum
Grant/Research: Celgene, Infinity, Kyowa-Kirin, Millennium, Seattle Genetics, Spectrum
Amit K. Verma, MBBS
Nothing to disclose.
The staff of CCME of Albert Einstein College of Medicine have no disclosures to report with any commercial interests relative to this CME activity.
Donald Harting, Writer/Editor, MCM Education, has no conflicts of interest to disclose.
Kathleen Hines, Vice President, Editorial Services, MCM Education, has no conflicts of interest to disclose.
Terry Ann Glauser, MD, MPH, Vice President, Medical Affairs, MCM Education, has no conflicts of interest to disclose.
ACCME ACCREDITATION STATEMENT: This activity has been planned and implemented in accordance with the requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through joint providership of Albert Einstein College of Medicine, Montefiore Medical Center, and MCM Education. Albert Einstein College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
ACCME CREDIT DESIGNATION STATEMENT: Albert Einstein College of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Commercial Support Statements
This activity is supported by independent educational grants from Pharmacyclics, Inc. and Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC., and Infinity Pharmaceuticals, Inc.
There are no fees for participating in or receiving credit for this online educational activity.
Participants must view/listen to the activity in its entirety, successfully complete the post-test, and submit an evaluation to receive continuing education credit. Credit will be awarded for a post-test score of 70% or better, and a statement may be printed immediately after passing the post-test online.
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Click on the "Start program" icon at the bottom of this page. If you are not already registered as a user of this website, this will bring you to the login/registration page where you will be able to register as a new CMEcorner.com member or review your existing registration information. When ready, click on the "Continue to Program" icon at the bottom of the screen. Alternatively, click on "Start as Guest."
The activity will take approximately 60 minutes to complete.
After the activity has finished, click on the "Post-test" button.
Instructions for completing and submitting the post-test and evaluation are provided on the post-test screen.
Presented by Albert Einstein College of Medicine & Montefiore Medical Center, Center for Continuing Medical Education, and MCM Education.
The opinions expressed in this educational activity are those of the faculty and do not necessarily reflect the opinions or recommendations of their affiliated institutions, the publisher, Albert Einstein College of Medicine & Montefiore Medical Center, Center for Continuing Medical Education, Pharmacyclics, Inc., Janssen Biotech, Inc., Janssen Scientific Affairs, LLC., or Infinity Pharmaceuticals, Inc. Any medications, diagnostic procedures, or treatments discussed by the program presenters should not be used by clinicians or other health care professionals without first evaluating their patients’ conditions, considering possible contraindications or risks, reviewing any applicable manufacturer’s product information, and comparing any therapeutic approach with the recommendations of other authorities.